????????????????è??(???é?????è??è￥??±?è?????)??¨?o??2?????3¨?????oé?·?¤???¨é???￠?( attention deficit hyper????act ivity disorder, ADHD) ???é????′?￥???§è?ˉ???????????¨????ˉ1???é?????è|??±?é???????￥???????3¨????2????????????????????????￡è?????é??????????oCYP 2D6?????????è??????????¨??￥???è?????è???????¤?ˉ1???é???????±?????

??????????1.???é?????è?370?????¤????????￥???é???°??1′??¨é?????????§??????????é?????è??è￥??±?????ˉ???￥??????é???o??o|??o0.5 mg/kg????1??????¨3?¤????????????¨é???1?????￠???????è?ˉé?????è?3?ˉ???￥????????????é??????o|??o1.2 mg/kg?????ˉ?ˉ???￥?????¨?????????è?ˉ????????¨??????????13????????o2????????¨??????é??è??è?.2 mg/kg/??￥??a????¤oé￠??¤????????¤???
???????????ˉ1?????￥???é???°??1′????ˉ???￥????¤§???é??????o?è??è?.4 mg/kg??00 mg???é???????-è???°?????????a???é????
??????????2.???é??è??è??70?????¤????????￥???é???°??1′???????oo??¨é?????????§??????????é?????è??è￥??±??ˉ???￥??????é???o???0 mg????1??????¨3?¤????????????¨é???1?????￠???????è?ˉé?????è?3?ˉ???￥????????????é??????o|??o80 mg????ˉ???￥?????¨?????????è?ˉ????????¨??????????13????????????????¨?????¨??§??-?????¨2-4??¨???????|??????aè????°?????3??????????ˉ???￥??????é??????¤§??ˉ??￥?￠??????°100 mg????2??????°?????ˉ?????¨??′é?????é?????????￠????????????

???????????ˉ1???é??è??è?0 kg????????￥???é???°??1′??￥???????oo????ˉ???￥????¤§??¨è????????é????o100 mg??

????????????′???/é??????2???? ???è???2?????ˉ1??§èˉ?éa????èμ????????¤oADHD??￡è???o??????¨?¤?é?????é?′??????é?????è??è￥??±???????è??é?????è?¤??o???ADHD??ˉè??é??è|?é????????è?ˉ????2????????|??????????é?????é??????????¨???é?????è??è￥??±?????o??????????èˉ???·é??????2?????ˉ1??￡è?????????????§??

?????????????é?????è??è￥??±???ˉ???é￡????????????????????????

??????????è?????è???????¤??￡è????????é??è°?è????

????????????′è?????è???????¨(HI)???ADHD??￡è????????é??è°?è????oè???|???? ?????-?o|HI??￡è?Child-Pugh Class B)???????§?????????????é???o?é??è?3???è§???¨é??ˉ1?????′HI?????￡è???0%???é???o|HI??￡è?Child-Pugh Class C)???????§?????????????é???o?é??è?3???è§???¨é?????25%??

???????????????oCYP 2D6?????????è??????????¨??????é??è°?è????

???????????????¨??oCYP 2D6??????????|???????è￥??±?????°?è￥??±?????￥??°?????????????é?????è?370?????¤????????￥???é???°??1′??????é?????è??è￥??±????????§????é???o???.5 mg/kg/????a???????¨???????????aè§???1????1????????§????é?????????￥????è???????§??????????￠????è?3é?????????????????é?.2 mg/kg/??￥??
???????????????¨??oCYP 2D6??????????|???????è￥??±?????°?è￥??±?????￥??°?????????????é??è??è??70?????¤????????￥???é???°??1′???????1′?oo??????é?????è??è￥??±????????§????é???o???0 mg/??￥????|????4??¨???????????aè§???1????1????????§????é?????????￥????è???????§????????ˉ?￠????è?3é?????????????????é?0 mg/??￥??
??????????????-￠?2?????????????é??é????????é????

???????????????￥??¨é??????????¨??????è?????é?????è??è￥??±?è????????????3¨????§??-|?????¨è?ˉ???è????°????￥?????2????????????